The reference site for Mesalamine

Mesalazine (INN, BAN), also known as mesalamine (USAN) or 5-aminosalicylic acid (5-ASA), is an aminosalicylate anti-inflammatory drug used to treat inflammatory bowel disease

WHAT IS Mesalamine?

Mesalamine (mesalazine) is an anti-inflammatory medication used to treat inflammation of the digestive tract (such as Crohn’s disease) and mild to moderate ulcerative colitis, proctitis, and proctosigmoiditis. It also helps prevent symptoms caused by the above from recurring.

Mesalazine is a bowel-specific aminosalicylate drug that is metabolized in the gut and has its predominant actions there, thereby having fewer systemic side effects. It works by affecting a substance in the body that causes inflammation, tissue damage, and diarrhea.

 

Brand Name(s): Asacol; Pentasa; Rowasa; Mesasal; Salofalk
CAS nº: 89-57-6
(me SAL a meen)

 

Product Info

The sections below will provide you with more specific information and guidelines related to mesalamine and its correct use. Please read them carefully.

FDA Information

Mesalamine was approved by the FDA in December 1987.

This medication is available with a prescription in the form of tablets, as suppositories, and as a rectal suspension. Its most commonly-known brand names include Asacol®Pentasa® and Rowasa®, but other brand and generic formulations are also available on the market.

Please visit the official site of the FDA for further information.

Why is this medication prescribed?

Mesalamine (mesalazine) is an anti-inflammatory medication used to treat inflammation of the digestive tract (such as Crohn’s disease) and mild to moderate ulcerative colitis, proctitis, and proctosigmoiditis. It also helps prevent symptoms caused by the above from recurring.

Mesalazine is a bowel-specific aminosalicylate drug that is metabolized in the gut and has its predominant actions there, thereby having fewer systemic side effects. It works by affecting a substance in the body that causes inflammation, tissue damage, and diarrhea.

Other uses for this medicine

This medication has not been approved for any alternative uses other than those mentioned in the product information section.

Dosage and using this medicine

Mesalamine is formulated for oral ingestion as tablets or capsules, and for rectal administration as rectal suppository, suspension or enemas.

Following rectal administration of mesalamine (by enema or suppository), only 15% of a dose is absorbed. Following oral administration, 28% of a dose is absorbed.

For tablets or capsules:

Take mesalamine exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose of mesalamine with a full glass of water. Additionally, each dose can be taken with or without food.

Do not crush, break, or chew the tablets or capsules. Swallow them whole. They are specially formulated to release the medication after they have passed through your stomach.

Notify your doctor if you repeatedly find undissolved tablets in your stool.

for rectal administration:

Try to empty your bowel just before using a rectal form of mesalamine.

Insert the suppositories rectally. Remove the foil wrapper and insert a suppository into the rectum, pointed end first. Avoid excessive handling of the suppository, because it is designed to melt at body temperature. Retain the suppository for one to three hours, or longer, if possible to get the maximum benefit from this medication.

Shake the rectal suspension well before use. Remove the protective cap from the applicator tip. Hold the bottle at the neck to prevent any of the medication from spilling out. Gently insert the tip into the rectum, pointing toward the belly button (umbilicus). Squeeze the bottle steadily to discharge most of the medication. Retain the suspension overnight if possible to get the maximum benefit from this medication.

Use this medication cautiously when applying the suppositories or rectal suspension. These products may stain clothing, flooring, painted surfaces, vinyl, enamel, marble, granite, and other surfaces.

The rectal suspension may darken slightly in color. Throw away any bottles that contain very dark brown liquid.

What special precautions should I follow?

BEFORE TAKING MESALAMINE:

Tell your doctor if you have any type of kidney disease. You may require a lower dose or special monitoring during your therapy with mesalamine.

Mesalamine is not known to interact with other medicines. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Use cautiously when applying the suppositories or rectal suspension. These products may stain clothing, flooring, painted surfaces, vinyl, enamel, marble, granite, and other surfaces.

Mesalamine is in the FDA pregnancy category B. This means that it is unlikely to harm an unborn baby. Do not take mesalamine without first talking to your doctor if you are pregnant.

Additionally, mesalamine passes into breast milk and may affect a nursing baby. Do not take mesalamine without first talking to your doctor if you are breast-feeding a baby.

What should I do if I forget a dose?

Take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the dose you missed and take only your next regularly scheduled dose.

Do not take a double dose of this medication.

What side effects can this medication cause?

If you experience any of the following serious side effects, stop taking mesalamine and seek emergency medical attention:

an allergic reaction (difficulty breathing, closing of your throat, swelling of your lips, tongue, or face, or hives)
worsening colitis (fever, abdominal pain, cramping, or bloody diarrhea)
chest pain or shortness of breath

Other, less serious side effects may be more likely to occur. Continue to take mesalamine and talk to your doctor if you experience:

nausea, vomiting, abdominal cramping, diarrhea, or belching
headache or dizziness
chills or sweating
a rash

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What storage conditions are needed for this medicine?

Always keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Please remember to throw away any medication that is outdated or no longer needed. If required, talk to your pharmacist about the proper disposal of your medication.

In case of an emergency/overdose

In the case of an overdose, call your local poison control center on 1-800-222-1222. However, if the victim has collapsed or is not breathing, please call the local emergency services on 911.

Symptoms of overdose may include:

ringing in the ears
dizziness
headache
confusion
drowsiness
sweating
hyperventilation
vomiting
diarrhea

Product Images

PICTURES OF MESALAMINE PRODUCTS

Below you will find images and specific information on the principal types of mesalamine that exist, including their respective brand name(s), strength, inscription codes, manufacturers and/or distributors.

The information below includes general information and guidelines for patients taking this medication and should never be used to substitute professional medical advice that can be provided by a qualified physician or family doctor.

 

Name: ASACOL®
Strength(s): 400 MG
Imprint: ASACOL
Manufacturer: P & G PHARMACEUTICALS

Name: PENTASA®
Strength(s): 500 MG
Imprint: PENTASA 500 MG
Manufacturer: SHIRE US INC.

Name: MESALAMINE
Strength(s): 4 G / 60 ML
Imprint: Mesalamine Rectal Suspension, USP
Manufacturer: TEVA USA

Name: MESALAMINE
Strength(s): 4 G | 60 ML
Imprint: Mesalamine Rectal Suspension, USP
Manufacturer: PERRIGO CO.

Name: ROWASA®
Strength(s): 4 G | 60 ML
Imprint: Mesalamine Rectal Suspension Enema
Manufacturer: SOLVAY PHARMACEUTICALS

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